George a Oswald
نویسندگان
چکیده
those without environmental insults or behavioural problems, as suggested in Drs Newell and Green's algorithm, diagnoses would have been missed. The three studies quoted were performed more than 10 years ago. Subsequent refinements in techniques of chromosome analysis allow identification of minor chromosome abnormalities that might previously not have been recognised-for example, in our series the X autosome translocation and the chromosome 15 deletion. We recently saw a childwith developmental retardation and hypotonia with no "hard" dysmorphic features who was 48, XXYY and aboywith mild retardation and pronounced behavioural disorder who was fragile (X) positive. Neither of these children would have had chromosomes checked under the algorithm. Boys with the fragile (X) syndrome may have fits, but these should not debar them from chromosome analysis. We would therefore recommended that chromosome analysis should be included in the routine investigation of children with mental retardation, irrespective of findings in the history or clinical examination. M A LAMoNT N R DENNIS
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